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    <ns6:brs_depositorOrganization xml:lang="en">Osaka Univ.</ns6:brs_depositorOrganization>
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    <ns1:expectedDelivery xml:lang="ja">D（6か月以上）</ns1:expectedDelivery>
    <ns4:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr01773'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns4:addinfo>
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    <ns1:strainDevelopment xml:lang="en">Developed by Hanjun Zhao, Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2001.  D3 ES cells were used to generate the knockout mice.</ns1:strainDevelopment>
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    <ns6:brs_depositor xml:lang="ja">野島　博</ns6:brs_depositor>
    <ns4:addinfo>&lt;A HREF="https://mus.brc.riken.jp/en/mouse_of_month/jan_2007_mm" target="_blank"&gt;Mouse of the Month Jan 2007&lt;/A&gt;</ns4:addinfo>
    <ns1:strainDevelopment xml:lang="ja">大阪大学微生物病研究所・Hanjun Zhao、薮田紀一先生、野島　博先生（2001）。D3 ES細胞を用いて作出。</ns1:strainDevelopment>
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    <ns6:brs_depositor xml:lang="en">Hiroshi NOJIMA</ns6:brs_depositor>
    <dc:description xml:lang="en">RECS1 (Tmbim1) gene knockout mice.  The 5’-untranslated sequence (-3.8 kb) and exon 1-6 region of RECS1 was replaced by PGK-neo cassette.  Homozygous mutant mice are prone to aortic dilation and cystic medial degeneration (CMD) when the mice ages (older than 14 months).  Aortic dilation and CMD are frequently encountered.  Viable and fertile.</dc:description>
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    <dc:description xml:lang="ja">RECS1 (Tmbim1) 遺伝子のノックアウトマウス。エクソン1から6をPGK-neoカセットで置換。ホモマウスは繁殖性、妊性あり。14ヶ月齢以上になると、血管中膜の嚢胞性の退行の傾向がある。</dc:description>
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    <ns1:colonyMaintenance xml:lang="ja">Heterozygote x Homozygote [or Crossing to C57BL/6NCrSlc]</ns1:colonyMaintenance>
    <ns1:colonyMaintenance xml:lang="en">Heterozygote x Homozygote [or Crossing to C57BL/6NCrSlc]</ns1:colonyMaintenance>
    <ns4:termsAndConditions xml:lang="en">The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. RECS1 deficiency in mice induces susceptibility to cystic medical degeneration. Hanjun Zhao et al. (2006) Genes Genet. Syst. 81, p41-50The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.</ns4:termsAndConditions>
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    <ns6:brs_depositorOrganization xml:lang="ja">国立大学法人大阪大学</ns6:brs_depositorOrganization>
    <ns4:termsAndConditions xml:lang="ja">条件を付加する。利用者は事前に寄託者の提供承諾書を得る。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。RECS1 deficiency in mice induces susceptibility to cystic medical degeneration. Hanjun Zhao et al. (2006) Genes Genet. Syst. 81, p41-50&lt;br&gt;共同研究。</ns4:termsAndConditions>
    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Approval form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns4:addinfo>
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